View abstract. There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. J Clin Lab Anal 2008;22:295-301. However, the review noted various limitations of the studies, including study design and potential bias. This is one of the more common food-drug reactions. There is animal research that suggests that ashwagandha may lower systolic and diastolic blood pressure, putting people who take blood pressure-lowering medication at risk for hypotension,. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Nonetheless, additional large-scale, long-term studies would strengthen these findings. Agarwal R, Diwanay S, Patki P, Patwardhan B. These severity listings are for informational use only. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. According to their lab study, withanone may interfere with DNA, leading to liver damage. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. J Ethnopharmacol. Gastrointestinal side effects including nausea, vomiting and diarrhoea. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. Ashwagandha: ADHD Uses, Warnings, Side Effects, Dosage - MedicineNet Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Serotonin syndrome can even result in death. 2003;19(3):211-222. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. This product may cause you to be sleepy. 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Supplements That Are Similar to Ashwagandha. What Vitamins Can You Not Take With Anti-Depressants? Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. PLoS One. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. 2009;15(4):423-430. 1998;20(1):191-198. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. Do not use this product if you have stomach problems or ulcers. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). Created for people with ongoing healthcare needs but benefits everyone. Ashwagandha: MedlinePlus Supplements Medicine (Baltimore). 2019;11(9):e5797. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. J Ethnopharmacol. Some research has proven that this may indeed be true. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . Ashwagandha: Benefits, Side Effects, and More - Verywell Health Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Hello! 1965;9(1):9-15. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. A November 2013 study in the Open Neurology Journal found that vitamin B12 could also help reduce symptoms of depression, while a March 2015 study in the Australian Journal of Herbal Medicine found that several B-complex vitamins could help reduce depressive symptoms. The concern would be blood pressure drops too lowif combining high blood pressure medications and ashwagandha. Sud Khyati S, Thaker B. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. The effect of standardized ashwagandha extract (35% withanolide glycosides) on fatigue, vitality and associated steroid hormonal systems in healthy aging, overweight men (40 to 70 years of age; BMI, 25 to 35) was investigated via a 16-week, double-blind, randomized, placebo-controlled crossover trial (N=57). 2014;20(12):901-908. doi:10.1089/acm.2014.0177, Remenapp A, Coyle K, Orange T, et al. 2021;270:113766. View abstract. Biogerontology. Talk with a healthcare provider about the right ashwagandha dosage for your needs. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. J Clin Med 2021;10(16):3644. Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. It is recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha out of an abundance of caution. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). Hidese S, Ogawa S, Ota M, et al. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. View abstract. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Monitor your blood sugar closely. These side effects are usually experienced on higher doses. Verywell Health's content is for informational and educational purposes only. Levothyroxine (Synthroid) Supplement Interactions -- Supplements To View abstract. Ashwagandha might lower blood pressure. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. Long-term safety studies on ashwagandha are lacking. Bjrnsson HK, Bjrnsson ES, Avula B, et al. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. View abstract. In the study, participants received either a placebo or 600 milligrams per day of ashwagandha for eight weeks. J Ethnopharmacol. Just be sure to choose a supplement from a reputable manufacturer and follow the . Ancient herb eases stress, boosts memory, and may help you lose weight. Integr Cancer Ther. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Harvard Health Publishing states that other medications, supplements and your diet all have the potential to affect the way your body processes your antidepressants. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. View abstract. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. TSH Suppression. Synthroid is not known to interact with these supplements. In recent years, some researchers have assessed how ashwagandha may benefit physical performance. View abstract. Drugs that cause sleepiness and drowsiness are called sedatives. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. Some products may not mix well with other drugs or natural products. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Ashwagandha might cause sleepiness and slowed breathing. Cureus. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. 2011;68(1):3-8. Phytother Res 1991;5:111-14. Hi, I was recommended to take ashwagandha. Although, it's important to note that long-term studies have not been performed on ashwagandha. Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. View abstract. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. It is essential to talk to your healthcare provider before taking ashwagandha if you are taking any other substances. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. The body naturally produces thyroid hormones. Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. A few commonly prescribed benzodiazepines are: Alprazolam (Xanax) Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Ireland PJ, Hardy T, Burt AD, Donnelly MC. Ultimately, the supplements and foods you can . Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. Use birth control you can trust while taking this product. Neurol India 2009;57:166-71. 1996;35(1):95-100. Expert Rev Clin Pharmacol. Ashwagandha has also been used to increase performance among athletes and improve male infertility. Does Ashwagandha interact with other medications? Find - Forest Raga Withania somnifera extract. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms. 2020;10(11):e01760. Staff. Akhgarjand C, Asoudeh F, Bagheri A, et al. doi:10.1002/brb3.1760, Adalier N, Parker H. Vitamin E, turmeric and saffron in treatment of Alzheimer's disease. Indian J Physiol Pharmacol. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. View abstract. View abstract. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. Ashwaganda and levothyroxine Interactions - Drugs.com Does Ashwagandha Interact With Any Medications? National Library of Medicines list 1992;30(3):169-172. View abstract. View abstract. For insomnia, a dose of 600 milligrams per day has been found to be safe and effective. Medically reviewed by Drugs.com. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. In comparison, a small human trial published in 2022 showed additional proof that ashwagandha may be helpful for people living with anxiety. This product can contain high amounts of iron. Dasgupta A, Peterson A, Wells A, Actor JK. This herb used in alternative medicine may help reduce stress. doi:10.1371/journal.pone.0257843, Verma N, Gupta SK, Tiwari S, Mishra AK. As with many other herbal supplements, little research is available on possible interactions. Additionally, ashwagandha may increase testosterone levels in the body. You will need to talk about the benefits and risks of using this natural product. View abstract. Doses higher than that may interact with lexapro, or produce more pronounced effects. ASHWAGANDHA: Overview, Uses, Side Effects, Precautions, Interactions Indian J Pharmacol. . Medical Content Reviewed By HelloPharmacist Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. Effect of Ashwagandha (Withania somnifera Dunal) on the process of ageing on human volunteers. Thank you, {{form.email}}, for signing up. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. Ashwagandha Uses, Benefits & Side Effects - Drugs.com Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. Health Sci Rep 2022;5(4):e741. Food Chem.Toxicol. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. View abstract. View abstract. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. Dietary supplements: what you need to know. There is concern that ashwagandha interacts with anesthesia commonly used in surgery. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Xanax. Aerobic capacity and recovery were assessed for all participants throughout the study. Who Shouldn't Take Ashwagandha? Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Ashwagandha may interact with various medications. They should also be kept from direct sunlight and stored in their original bottle or container. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ashwagandha May Interact With Certain Drugs. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. 2021;16(9):e0257843. Ultimately, the supplements and foods you can safely ingest depend entirely on the antidepressant. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Mandlik Ingawale DS, Namdeo AG. J Ethnopharmacol 1999;67:233-39. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. View abstract. Indian J Exp Biol 1997;35:236-9. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Does Ashwagandha Interact With Any Medications? In fact, according to the book Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, published in 2010 by the British Psychological Society, there are no specific vitamins contraindicated for consumption with antidepressants. When to Take Ashwagandha: Morning or Night? - Healthy Directions From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! View abstract. Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. In rare cases, the use of ashwagandha may lead to liver damage. 2019;98(37):e17186. Indian J Physiol Pharmacol. For most people, ashwagandha is a safe and effective supplement for taking the edge off stress. This interference is likely due to a similarity in chemical structure, according to Drugs.com. It may also interact with medications for these conditions. Ashwagandha is popular in Ayurveda medicine, and Indians have used it for more than 3,000 years to treat a wide range of healthy disorders. J Ethnopharmacol 1999;67:27-35. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. Several supplements and herbs may act similarly to ashwagandha. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. View abstract. For example, it may increase the sedative effect of medications that treat anxiety and insomnia. View abstract. If you take a drug meant to suppress your immune systems, such as methotrexate or mycophenolate, they may have conflicting effects. It is also recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha due to possible hormone changes caused by the herb. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. View abstract. Feel free to send him an email at Hello@HelloPharmacist.com! Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. The specific components of physical performance included strength and power, endurance, and fatigue/recovery. According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative . 2018 Mar;24(3):243-248. Kulkarni RR, Patki PS, Jog VP, et al. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. J Med Food 2022. 2021;51(4):363-365. Go to the ER right away. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. View abstract. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. ashwaganda: Dosing, contraindications, side effects, and - Epocrates Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. Ashwaganda is used to treat Herbal Supplementation. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. View abstract. 1965;9(3):127-136. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Ashwagandha may increase thyroid hormone levels. Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Skinmed. Do note that ashwagandha itself does not . View abstract. Is it safe to take ashwagandha every day? View abstract. J Obstet Gynaecol Res 2021. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. It is very widely utilized as a dietary supplement and used for a number of purported medical benefits, including: As ashwagandha is a botanical, it appears to have many different active components and a complex mechanism of action for how it works. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. Take extra care if you are using drugs to help you relax or sleep. Ashwagandha has mild interactions with at least 29 different drugs.

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