Results: The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. > 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). Upgrade to Rappler+ for exclusive content and unlimited access. [31] The results will be interpreted carefully based on several explanations for funnel plot asymmetry. V03AX - Other therapeutic products ; Other products with therapeutic properties. Tips: Please read the directions for use in retail or directed by physician. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. The studies that do not fulfill the inclusion criteria will be excluded and listed with reasons for their exclusion. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. [Efficacy and safety of Lianhua Qingwen capsule for influenza a Avoid spicy & greasy food during medication. 2023 Feb 17;2023:6028554. doi: 10.1155/2023/6028554. BMC Complement Altern Med 2017;17:130. Records from databases and other resources will be uploaded to a database created by EndNote9.7 software. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. We first used Rhubarb to cure the disease, dredge the internal organs and relieve the heat, and then made Huoxiang fragrant and moistening. In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. In 2009, Diagnosis and Treatment Scheme for Patients Infected with Type A H1N1 Influenza (2009), issued by the State Administration of traditional Chinese medicine Avoid receiving nourishing Chinese medicine during the period in this product. It has been recommended as a recommended drug for the diagnosis and treatment of pneumonia caused by a new coronavirus (which has been included in the fifth, sixth, and seventh edition of the diagnostic and therapeutic plan version). Epub 2021 Nov 2. Designed by ACTSmarket. Used in the patterns of heat toxin assailing the lung in influenza, manifested as fever or high fever, aversion to cold, muscular soreness, stuffy and runny nose, cough, headache, dry and sore throat, reddish tongue, yellow or yellow and greasy tongue coating. The capsule is hugely popular and controversial as it traces its roots to a prescription that date back to classic medical texts written during the Han dynasty (206BC220AD), according to a report from the South China Morning Post. Lianhua Qingwen Capsules can significantly improve the total effective rate for COVID-19 patients, as well as shorten the hospital stay and treatment time, which is worth of promotion in the clinic. Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. Already have Rappler+? Aside from the Philippines, the Lianhua Qingwen Capsule has been approved in Hong Kong and Macau, Brazil, Indonesia, Canada, Mozambique, Romania, Thailand, Ecuador, Singapore and Lao. Cao B, Zhang D, Wang C. A trial of lopinavir-ritonavir in, [6]. Even if symptoms of fever, fatigue and cough end earlier, please continue to complete an 8-day course to help the body recover.For children younger than 14 years old, we recommend that you consult a TCM physician on the dosage since the body condition differs from each child. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. [Package]Aluminium-plastic package, 24 capsules/box, [Executive Standard]Chinese Pharmacopoeia 2010, the 2nd supplemental volume. Chinese Journal of pharmacology and toxicology 2015;29:2137. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. 10 Consultancy by Fixx Digital The .gov means its official. Do not use this product if the property changed. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. In addition, it can also interact with other compounds and herbs. [21]. Hongying Mo, Changwen Ke, Jinping Zheng, et al. Drug discoveries & therapeutics 2020;14:6772. Egger M, Davey Smith G, Schneider M, et al. Chinese supplement Lianhua Qingwen: What you need Chinese Journal of nosocomial infection 2015;25:7279. may email you for journal alerts and information, but is committed For oral use after meals,4 capsules one time and thrice daily. The results will be cross-checked by the 2 reviewers, and any disagreements will be resolved by consensus, with any ongoing differences in opinion being arbitrated by a third reviewer (LMJ). Used for patterns of heat toxin assailing the lung in flu, manifested as fever, aversion to cold, muscle soreness, stuffy & runny nose, cough, headache, dry & sore throat, reddish tongue, yellow & greasy tongue coating. Lianhua Qingwen Capsule - Yiling Treatment of Pediatric Diseases, 2017, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2016, the Phase II Clinical Trial for Lianhua Qingwen approved by US FDA started in Virginia in the US in September, 2015, recognized as a recommended product in the Expert Consensus Document on Treatment of Cold in Special Populations, 2015, recognized as a recommended product in the Standard Therapy for Middle East Respiratory Syndrome, 2014, recognized as a recommended product in the Standard TCM Therapy for Ebola Virus Infections, 2014, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Expert Consensus Document on Medical Rescuing of Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2012, recognized as a recommended product in the Standard TCM Therapy for Influenza B Virus Infections, 2011, recognized as a recommended product in the Guideline on Diagnosis and Treatment of Influenza, 2010, recognized as a recommended product in the Standard Therapy for Rheumatic Fever (Non-severe Community Acquired Pneumonia), 2009, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Influenza A H1N1, 2008, recognized as a recommended product in the Instructions on Use of TCM Therapies for Prevention and Treatment of Diseases after an Earthquake, 2008, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza (2008), 2005, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza, [Drug Name]Generic name: Lianhua Qingwen Capsules. WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba 2020 Sep 11;15(9):e0238828. CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment periods. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). In the analysis, we will exclude lower-quality trials and repeat the meta-analyses to examine whether the quality of included studies influences the pooled results. A trial of lopinavirritonavir in adults hospitalized with severe. 4. patients: total number and number in both groups, baseline characteristics, diagnostic criteria, withdrawals, and losses to follow-up (reasons, description); 5. outcomes: outcomes specified above, adverse drug reactions, and adverse time, length of follow-up, quality of reporting of outcomes. Data is temporarily unavailable. In 2005, Diagnosis and Treatment Scheme for Patients Infected with Avian Influenza (2005), issued by the Ministry of Health, Famous Kazakhstan journalist talks about Lianhua, New Progress in Study on Mechanism of Lianhua Qingwen Capsules for Treatment of COVID-19, TCM (Traditional Chinese Medicine) received by Cambodia for treating COVID-19 patients. [33]. MJL will arbitrate any disagreement and ensure that no errors occur during the review. XLZ and JNL will assess the risk of bias and perform data synthesis. Forsythiae Fructus, Lonicerae Japonicae Flos, Ephedrae Herba (processed with honey), Armeniacae Semen Amarum (stir-baked), Gypsum Fibrosum, Isatidis Radix, Dryopteridis Crassirhizomatis Rhizoma, Houttuyniae Herba, Pogostemonis Herba, Rhei Radix et Rhizoma, Rhodiolae Crenulatae Radix et Rhizoma, l-Menthol, Glycyrrhizae Radix et Rhizoma. Sofia Tomacruz covers defense and foreign affairs. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. Individuals w/ cold deficiencies in spleen & stomach or w/ qi. The manuscript was drafted by XLZ and MJL. Unable to load your collection due to an error, Unable to load your delegates due to an error. We plan to carry out the following subgroup analyses if possible: the study area is different, the average course of disease is different, and the length of treatment is different. Placebo, routine western medicine therapy, and other therapeutic methods in the comparators (drugs, dose, frequency, duration); (5) Outcomes: the primary outcomes include total efficiency, primary symptoms, and Keyword Highlighting It has important clinical application value to treat patients with covid-19. In this study, 100 participants were To add, theonline sale and distribution ofthis productis prohibited and those engaging in this activityviolatethe R.A.10918orPhilippine Pharmacy Act. PMC Highlight selected keywords in the article text. Asia's one-stop resource for medical news, clinical reference and education, Click to view Lianhua Qingwen detailed prescribing information. Max: 7 days. Also,its packaging is in Chinese characters and needs to comply with FDAs labeling requirements written in English. Careers. We will judge the each domain as low risk of bias, high risk of bias," or uncertain risk of bias" according to Higgins (2011), and pay particular attention to the risk of bias of cluster-randomised trials. Lianhuaqingwen (LHQW) has anti-inflammatory and immune regulatory functions and may inhibit the airway inflammation that occurs during an acute exacerbation of COPD. A funnel plot will be constructed and examined to assess publication bias and possible small study biases if the group include more than 10 trials. Would you like email updates of new search results? A few patients have cough, expectoration, chest distress, dyspnea, muscle ache, diarrhea, and other symptoms. A park employee (R), seen wearing goggles and face mask, walks in a park in Beijing on March 14, 2020. (4) intervention characteristics: Lianhua Qingwen in the treatment group (dosage form, dose, frequency, duration). Go and see the doctor if the symptom is not alleviated 3 days after administration. Traditional Chinese medicine, such as Lianhua Qingwen, has achieved some curative effect in many countries, but its effect is not clear. Dichotomous outcomes will be presented as risk ratio and 95% confidence intervals (CIs), and continuous outcomes will be presented as mean difference/standard mean difference and 95% CIs. Efficacy and safety of Lian-Hua Qing-Wen granule for Nevertheless, this systematic view should help further expand our understanding of Lianhua Qingwen combined with conventional antiviral Western Medicine treatments in COVID-19 and asymptomatic infection. Please be informed that only the [22]. Announcement of the national health and Health Commission of the people's Republic of China [EB /OL] (2020-01-20) [20200217]. The treatment of influenza using the TCM patent product Lianhua Qingwen won the Second-class Prize of the National Science and Technology Progress Award in 2011. Experimental study of Lianhuaqingwen capsule against influenza A virus in vitro [J]. Higgins JPT, Thompson SG, Deeks JJ, et al. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. Teresa May Bandiola is a licensed pharmacist, a published writer, and a university instructor. Ephedra increases heartbeat and blood pressure. The independent Newcastle Ottawa scale was used to conduct methodological quality assessment of nonrandomized trials. When the dose was administered at 150, 300, and 600 g/mL, it significantly inhibited the expression of SARS-CoV-2 in a dose-dependent manner, and inhibited the formation of plaques in virus-infected cells, confirming that Lianhua Qingwen significantly inhibited SARS-CoV-2 activity in vitro. Conclusion: Delivery takes 2 business days & another 2 calendar days for order processingPROMO OFFER ( completed & over) : Buy 1 Bundle, We Donate 1 Bundle ! Effectiveness and Safety of Lianhua Qingwen Capsules for COVID-19: A Propensity-Score Matched Cohort Study. This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. Below dosage is a guide only. 2020 Jul 24;99(30):e21404. Your message has been successfully sent to your colleague. WebLianhua Qingwen Jiaonang with Chinese Characters; As per continuing post-marketing surveillance, there is still incessant sale and distribution even through social media platforms, such as Facebook, of Lianhua Qingwen Jiaonang with Chinese characters, which were verified as unregistered by the FDA. Particularly, when ephedrine is combined with caffeine (coffee), itcan lead to significant cardiovascular, metabolic, and hormonal responses. Avoid alcohol and tobacco and spicy,cold, greasy food during taking this product. National Library of Medicine ACTSmarket.com is the e-shop and distribution arm of ACTSmarket Ltd, In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission a non-profit social enterprise that collaborates with other SE producers to build capacity in marketing, sales and operations. You may search for similar articles that contain these same keywords or you may All tests are 2-tailed, and P < .05 is considered statistically significant. Common side effects are heart palpitations, nausea, and vomiting. Unauthorized use of these marks is strictly prohibited. The Chinese embassy likewise advised the public to only purchase and consume authentic traditional Chinese medicine produced by qualified pharmaceutical manufacturers. Molecules. China's top respiratory expert, the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. Second Prize of National Science and Technology Progress Awards [23]. Treatment of Sars-Cov-2: how far have we reached? Wu C, Chen X, Cai Y, et al. PRISMA flow diagram of study and exclusion. Chinese Journal of experimental pharmacology 2015;21:13943. We may also contact the original authors to provide additional relevant information, if necessary. [30] The I2 statistic of <50% indicates a low level of statistical heterogeneity, and that of 50% will be considered substantial statistical heterogeneity. Removes heat-toxin invasion of the lungs, including symptoms eg, fever, aversion to cold, muscle soreness, stuffy & runny nose. If meta-analysis is not applicable, we will conduct a systematic narrative synthesis providing information to summarize and explain the characteristics and findings of the included studies. Kunming: Kunming University of technology; 2015. COVID-19; Lianhua Qingwen; clinical symptoms; retrospective study; total effective rate; traditional Chinese medicine (TCM) treatment. Pregnancy & lactation. Even For patients showing mild symptoms, Lianhua Qingwen would be more effective. All patients must be diagnosed with prediabetes by clearly defined or internationally recognized criteria. Novel coronavirus pneumonia treatment plan issued by the national health and Health Committee, State Administration of traditional Chinese medicine (trial version sixth) [EB/OL]. [16] Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. Because the novel coronavirus pneumonia has not yet been completely subsided, more large-sample clinical studies are still ongoing. The registered Chinese capsule Lianhua Qingwen that has been approved should have the FDAs labeling requirements written in English, Domingo said. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health. Lianhua Qingwen Jiangnan (LHQW) for Flu and Colds [33] Previous pharmacodynamic studies have confirmed that Lianhua Qingwen capsule can significantly inhibit the SARS CoV virus in cultured cells in vitro, and has a significant inhibitory effect on H1N1, H3N2, h7n9, and other influenza viruses,[3436] indicating that Lianhua Qingwen capsule has played an important role in the prevention and control of public health events of respiratory system caused by virus. Wang Y, Zhang D, Du G, et al. The COVID-19 may improve the clinical symptoms associated with fever, cough, and fatigue. Chest radiographs. The two groups were compared in terms of clinical effects and main symptom (fever, cough and fatigue) disappearance rate. It has a history of abuse by athletes due to its ability to increase energy and alertness and help weight loss. government site. Coronavirus disease 2019 (, [5]. Lianhua Qingwen capsule (granule) is an Innovative Patent Chinese medicine for the treatment of influenza, which was developed by the green channel of the new drug approval during the SARS period in 2003 based on the pathology of collateral of traditional Chinese medicine. Please enable it to take advantage of the complete set of features! Lianhua Qingwen Capsule for pneumonia [15]. Also illustrates the potential biases within each of the included studies by presenting a risk of bias," table, graph, and summary. Use left/right arrows to navigate the slideshow or swipe left/right if using a mobile device. The novel coronavirus pneumonia (COVID-19) has spread to >200 countries and regions. WebTo evaluate the efficacy and safety of Lianhua Qingwen capsule for influenza. A: Before treatment; B: After treatment. According to the Cochrane Handbook bias risk assessment tool, bias risk is independently assessed. Ephedra was banned from the Olympics and other sport events, even in the US military. Henan traditional Chinese medicine 2007;27:356. For RCTs, the Cochrane Collaboration's tool for assessing risk of bias will be used; 2. Progress in pharmacology and clinical research of Lianhuaqingwen capsule [J]. The Cochrane Collaboration, Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions (Version 5.1.0). WhileDDB notes the FDAs approvalofLHQWas a traditional herbal product that may helprelievefever, muscle soreness, stuffy and runny nose associated with Covid-19, the DDBalsobelievesinpreventing diversion and unsafe use and abuseof this product withouthampering theaccess toit. However, this systematic review will have some limitations. eCollection 2020. Available at: [16]. This product is capsule, brown to yellowish brown particles and powder inside;smell slightly fragrant, slightly bitter taste. http://creativecommons.org/licenses/by/4.0. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Novel coronavirus pneumonia treatment plan (revised version 7) [EB/OL]. Lianhua Qingwen 3.Patients with common cold due to wind-cold dont apply to the product. Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. "It's the first time in the world that we have enough evidence to prove Lianhua Qingwen Jiaonang capsule is effective and can help patients recover," Zhong said, adding they have just finished an experiment and the results are promising and werepublished. Copyright 2023 MIMS Pte Ltd. All rights reserved. [Manufacturer]Company name: Shijiazhuang Yiling Pharmaceutical Co., Ltd. Writing review & editing: Xiaolin Zhang. | 2023 ACTSmarket, capsules x 3 times a day ( after breakfast, lunch and dinner. National Key New Product System searches CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as ChiCTR, NTR and clinical Trials.gov. Zhongguo Zhong Yao Za Zhi. Therefore, the completeness of the evidence is not yet available. Disclaimer. Patients with hypertension or heart disease should use with caution, patients with chronic disease such as diabetes, liver disease, kidney disease should take medicine under doctors direction. Dont take this medicine if the description has changed. BBD Aug 2024. For NRIs, evaluate its methodological quality with the Newcastle Ottawa scale (NOS). WHO Director-General's opening remarks at the media briefing on. Patients with body temperature higher than 38.5 should see the doctor. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment course. It is not necessary for ethical approval because this article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. Data synthesis reports the intervention effect of the original study by integrating the cohort study. [14]. Lianhua Qingwen - Wikipedia [18]. The 700 boxes of LHQW are sponsored by Yiling Pharmaceutical Co. Ltd (China) and the local distributorKinhong Pte Ltd. You may be trying to access this site from a secured browser on the server. It is also for prevention of low blood pressure during anesthesia. Also excluded are studies enrolling <30 participants. Consume daily after meal Lianhua Qingwen formula is based on the theory of collateral disease, to reveal the law of transmission of respiratory infectious diseases caused by virus. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. Web[Strength] 0.35g/capsule [Administration and Dosage] For oral administration, 4 capsules once, 3 times daily [Adverse Reactions] Unclear [Contraindications] Unclear [Precautions] 1. 10. Zhang, Xiaolin MDa,; Cao, Di MMb; Liu, Junnan MMa,c; Zhang, Qi MDa; Liu, Mingjun PhDa,, aChangchun University of Chinese Medicine. Wu Yiling. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment Among the many commonly used TCMs, the most commonly used one is Lian-Hua Qing-Wen Granule (LHQWG). For the treatment of COVID-19, the main effects of Lianhua Qingwen are as follows: First, after taking the capsule, patients' symptoms improve quickly, two days earlier than the control group. Second, CT scan result also shows that patients recover faster than the control group. Third, the capsule can shorten fever time. XLZ conceived of the study, and perform this review. Lianhua Qingwen combined with conventional antiviral Western Medicine may be a useful treatment for prediabetes. We aim to assess the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in Clinical treatment of COVID-19 or asymptomatic infection. Lianhua Qingwen prescription for Coronavirus disease SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD. Lianhua Qingwen, a representative TCM patent product for the treatment of influenza. All reports of the randomized controlled trials (RCTs) on Lianhua Qingwen capsule treating influenza Press the space key then arrow keys to make a selection. Early Treatment>14 years & above:4capsules x 3 times a day ( after breakfast, lunch and dinner) for7 to 10 days. HHS Vulnerability Disclosure, Help 9 Experimental research also showed that LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function. Lianhua Qingwen It has a wide-spectrum antiviral, effective antibacterial, antipyretic and anti-inflammatory, antitussive and expectorant, immune-regulating and other systemic intervention functions,[1625] especially for the coronavirus SARS[26] And Middle East respiratory syndrome (MERS)[27] have significant inhibitory and killing effects. A: Chest radiograph of normal people; B: Chest radiograph of a. Contraindicated for the patients allergic to this product, be cautions about patients with allergic constitution. Choosing a selection results in a full page refresh. National Health and Family Planning Commission of the people's Republic of China. Consult with doctors or pharmacists before administration if other medicines are received during this time. Lu Y, Zhang M, Yang QQ, Li WJ, Yang K, Hu W, Gao SY, Jiang QL, Lin LK, Cheng H, Sun F. Evid Based Complement Alternat Med. In the fifth edition of COVID-19's diagnosis and treatment guideline issued by the China Health Commission, LHQWG is listed as one of the recommended medicine

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